Protein Details: Potassium channel subfamily K member 2

Function

Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes;forms mostly heterodimeric potassium channels with KCNK1;with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes;the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors;such as F2R and CNR1 (By similarity). [Isoform 4]: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Sequence

PDB Structures

Ligand Binding